Introduction by Co-Chairs

Oral communications session - Clinical Trials Therapeutics and Interventions

Jeff Cummings, University of Nevada Las Vegas (UNLV) – Las Vegas, NV (United States)
Atsushi Iwata, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo (Japan)

OC01 — Multistrain Probiotic Supplementation and Neurobiomarker Modulation in Alzheimer Disease–Related Cognitive Impairment: A Double-blind, Randomized, Controlled trial

Kun Ho LEE^1,2, Kang-Ho CHOI³

¹Gwangju Alzheimer’s Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju, Korea, Republic of; ²Department of Biomedical Science, Chosun University, Gwangju, Korea, Republic of; ³Department of Neurology, Chonnam National University Hospital and Medical School, Gwangju, Korea, Republic of

OC02 — Clinical Management Pathway for Subcutaneous Lecanemab Injection in Patients with Alzheimer's Disease: A Chinese Multidisciplinary Delphi Expert Consensus

Cuibai WEI¹, Yong JI², Yan HOU³, Qin CHEN⁴, Huayan LIU⁵, Jun LIU⁶, Shuai LIU², Su LUI⁴, Guoping PENG⁷, Yuchen QIAO¹, Lu SHEN⁸, Li SUN⁹, Huidong TANG¹⁰, Xiaochun CHEN¹¹, Jianping JIA¹

¹Xuanwu Hospital, Capital Medical University, Beijing, China; ²Huanhu Hospital Affiliated to Tianjin Medical University, Tianjing, China; ³School of Public Health, Peking University, Beijing, China; ⁴West China Hospital of Sichuan University, Chengdu, China; ⁵The First Hospital of China Medical University, Shenyang, China; ⁶the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China; ⁷The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; ⁸Xiangya Hospital, Central South University, Changsha, China; ⁹The First Hospital of Jilin University, Changchun, China; ¹⁰Ruijin hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ¹¹Fujian Medical University Union Hospital, Fuzhou, China

OC03 — Sodium Oligomannate Improves Cognitive function via Remodeling Gut Microbiome in Patients with Mild-to-moderate Alzheimer’s Disease Dementia

Heling CHU¹, Chuyi HUANG², Qihao GUO³

¹Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine - Shanghai (China), Shanghai, China; ²Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; ³Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

OC04 — A Common Core, Tailored Delivery: Co-creating and Prototyping SINGER for Active Ageing Centres in Singapore

Kwong Hsia YAP¹, April Ka Sin PHUA², Erin Heh Ying HUM¹, Evangeline Hui Jie ONG¹, Adabel Kai Ying TAN¹, Christopher Li Hsian CHEN¹

¹National University of Singapore, Singapore, Singapore; ²National University Hospital, Singapore, Singapore

OC05 — Multidimensional Evaluation of Cervical Shunting to Unclog cerebral Lymphatic Systems (CSULS) surgical procedure in Alzheimer’s Disease: A 12-Month Single-arm Prospective Study

Yan CHEN, Yuan FANG, Feng YAN, Xia LI

Shanghai Mental Health Center, Shanghai, China

OC06 — Translating person-centered outcomes for AD trials: Cross-cultural feasibility of the ePSOM tool in Japanese memory clinics

Yuki TAKEDA¹, Hisatomo KOWA¹, Atsushi IWATA², Norio CHIHARA¹, Himanshi MALIK³, Ali JANNATI³, Claudio TORO-SEREY³, Sean TOBYNE³, Ricky KURZMAN⁴, Yosuke NAKAMURA⁵, Jo VANDERCAPPELLEN⁵, Alvaro PASCUAL-LEONE³, Stina SAUNDERS³

¹Kobe University Graduate School of Medicine, Kobe, Japan; ²Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan; ³Linus Health Inc., Boston, United States; ⁴Eisai Inc., Nutley, United States; ⁵Eisai Co Ltd, Tokyo, Japan

Introduction

Oral communications session – Clinical Trials Biomarkers

Lefkos Middleton - Imperial College London, London (United Kingdom)

OC07 — Dual White Matter Hyperintensity and p-tau217 Burden Is Associated with Cognitive Frailty and Longitudinal Decline

Xin Tong TAN^1,2, Li YAN^1,2, Mitchell Kim Peng LAI^1,2, Christopher Li Hsian CHEN^1,2

¹Memory, Ageing & Cognition Centre, National University Health System, Singapore, Singapore, Singapore; ²Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

OC08 — Proteomic Signatures of Cognitive Domains: Towards a Domain-specific Biomarker Framework

Bang ZHENG¹, Lefkos MIDDLETON²

¹Peking University, Beijing, China; ²Imperial College London, London, United Kingdom

OC09 — Neuronal Pentraxin Receptor: a Disease-Specific Biomarker of Neurodegeneration and Clinical Progression Across Alzheimer's Disease Continuum

Feng GAO¹, Linbin DAI¹, Bjørn-Eivind KIRSEBOM², Qiong WANG¹, Fernando GONZALEZ-ORTIZ³, Kaj BLENNOW³, Jiong SHI¹, Tormod FLADBY², Yong SHEN¹

¹The First Affiliated Hospital of USTC, Hefei, China; ²The Arctic University of Norway, Tromsø, Norway; ³The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

OC10 — Diagnostic accuracy of Elecsys pTau181 and pTau217 plasma assays using global cutoffs in an Asian cohort: Results from the K-ROAD registry

Jun Pyo KIM¹, Gwendlyn KOLLMORGEN², Christian KUFFER², Annunziata DI DOMENICO³, Myrto ANDREADOU³, Tobias BITTNER^4,5, Sayuri HORTSCH², Sang Won SEO¹

¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of; ²Roche Diagnostics GmbH, Penzberg, Germany; ³Roche Diagnostics International Ltd, Rotkreuz, Switzerland; ⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland; ⁵Genentech, Inc., South San Francisco, California, United States

OC11 — Plasma brain-derived pTau217 detects abnormal brain amyloid burden with high accuracy and predicts cognitive decline in a Singapore cohort

Joyce R. CHONG^1,2, Saima HILAL³, Narayanaswamy VENKETASUBRAMANIAN⁴, Xiao-Jun MA⁵, Christopher P. CHEN², Mitchell K.P. LAI²

¹Wisconsin Alzheimer’s Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States; ²Memory, Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; ³Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; ⁴Raffles Hospital, Raffles Neuroscience Centre, Singapore, Singapore; ⁵Alamar Biosciences, Inc, Fremont, United States

OC12 — Difference of Cerebrospinal Fluid Biomarkers and Neuropsychiatric Symptoms Profiles among Normal Cognition, Mild Cognitive Impairment, and Dementia Patient

Ching-Chi HSU¹, Shiow-Ing WANG², Hong-Chun LIN³, Eric S. LIN⁴, Fan-Pei YANG⁴, Ching-Mao CHANG⁵, James Cheng-Chung WEI⁶

¹Wizcare Hospital, Taichung, Taiwan; ²National Tsing Hua University, Hsinchu, Taiwan; ³Taipei Veterans General Hospital, Taipei, Taiwan; ⁴National Tsing Hua University, Hsinchu, Taiwan; ⁵National Yang Ming Chiao Tung University, Taipei, Taiwan; ⁶National Yang Ming Chiao Tung University, Taichung, Taiwan

Introduction

Oral Communication Session: Healthy Longevity

Introduction Bruno Vellas – IHU HealthAge – Toulouse (France)

OC13 — DL-Derived Neurodegenerative and Cerebrovascular Brain Ages Enhance Dementia Progression Prediction

Yichi ZHANG¹, Fang JI¹, Joanna Su Xian CHONG¹, Joyce Ruifen CHONG^1,2, Eric Kwun Kei NG¹, Mayank DALAKOTI³, Boon Yeow TAN⁴, Narayanaswamy VENKETASUBRAMANIAN^5,6, Arthur RICHARDS^7,8, Roger FOO³, Michael CHEE¹, Mitchell Kim Peng LAI^1,5, Thomas YEO^1,9, Christopher CHEN^1,5, Juan Helen ZHOU¹

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; ²School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States; ³Department of Cardiology, National University Heart Center, Singapore, Singapore; ⁴St Luke's Hospital, Singapore, Singapore; ⁵National University Health System, Singapore, Singapore; ⁶Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore; ⁷Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore; ⁸Christchurch Heart Institute, University of Otago, Dunedin, New Zealand; ⁹Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States

OC14 — Greater Modifiable Dementia Risk-Factor Burden Is Associated With Poorer Cognition and Higher Circulating p-Tau217 and Neurofilament Light Chain

Reshma MERCHANT¹, Bruno VELLAS²

¹NUHS, Singapore, Singapore; ²IHU HealthAge, Toulouse, France

OC15 — Artificial Intelligence based Retinal Imaging Biomarker Identifies Suboptimal Brain Health and Improves Response to Lifestyle Intervention

Yuan CAI^1,2, Yuen Tung NG^1,2, Ying Hong CHAN^1,3, Wing Yin CHAN^4,3, Huijing ZHENG⁵, Adrian WONG¹, Mandy Yuen Ting LAU^6,3, Lili FANG^1,3, Anran RAN⁷, Julia Yujiahui AYMARD^8,4, Chloe Yui Ching LAM^9,4, Ho KO^1,3, Carol Yim Lui CHEUNG⁷, Vincent Chung Tong MOK^1,3

¹Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; ²Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Gerald Choa Neuroscience Institute, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China; ³Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Gerald Choa Neuroscience Institute, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China; ⁴Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital - Hong Kong (China), Hong Kong, China; ⁵School of Computer Science and Statistics, Trinity College Dublin, College Green, Dublin D02 PN40, Dublin, Ireland; ⁶Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital - Hong Kong (China) - Hong Kong (China), Hong Kong, China; ⁷Department of Ophthalmology and Visual Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China; ⁸Department of Psychology, Faculty of Arts and Sciences, Concordia University, Montreal, Quebec, Canada; ⁹Department of Biological Sciences, Department of Psychology, University of Toronto Scarborough, Toronto, Canada

LB Communication LB01

OC16 — Multimodal subtyping reveals distinct subtypes of Alzheimer’s and cerebrovascular disease

Joanna Su Xian CHONG^1,2, Fang JI^1,2, Saima HILAL^3,4, Joyce Ruifen CHONG⁵, Fiona Jia Wen GOH^1,2, Boon Yeow TAN⁶, Narayanaswamy VENKETASUBRAMANIAN^7,8, Mitchell Kim Peng LAI⁵, Christopher Li-Hsian CHEN⁵, Juan Helen ZHOU^9,10

¹Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; ²Human Potential Translational Research Programme and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; ³Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; ⁴Memory, Ageing and Cognition Centre, National University Health System, Singapore & Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore; ⁵Memory, Ageing and Cognition Centre, National University Health System, Singapore & Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore; ⁶St. Luke’s Hospital, Singapore; ⁷Memory, Ageing and Cognition Centre, National University Health System, Singapore; ⁸Raffles Neuroscience Centre, Raffles Hospital, Singapore; ⁹Centre for Sleep and Cognition, Centre for Translational Magnetic Resonance Research, Human Potential Translational Research Programme and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; ¹⁰Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School and Department of Electrical and Computer Engineering, National University of Singapore

OC17 — From Incomplete Data to Detection: The Role of a Transformer-based Tabular Foundation Model in Cognitive Impairment Prediction

Jing Jie TAN, Ngai Yiu Enoch MOK, Saima HILAL

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore

OC18 — Elecsys pTau217 plasma assay cutoff determination and validation for the detection of amyloid pathology in a Chinese population

Jiawei XIN¹, Yuyuan HUANG², Xuhui CHEN³, Ming GUAN², Chuantao ZUO², Yingping CAO¹, Zhongyou JI¹, Mengjie DONG³, Jun HU³, Guoyu LAN⁴, Qiman YIN⁵, Yim YUNG⁵, Xiaochun CHEN¹, Jintai YU², Tengfei GUO⁴

¹Fujian Medical University Union Hospital, Fuzhou, Fujian, China; ²Huashan Hospital affiliated to Fudan University, Shanghai, China; ³Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; ⁴Shenzhen Bay Laboratory, Shenzhen, Guangdong, China; ⁵Roche Diagnostics (Shanghai) Ltd, Beijing, China

OC19 — Peri-infusion Blood Pressure Reactivity during Lecanemab Treatment: A Cerebrovascular Signal in a Korean Real-World Cohort

So Yeon JEON, Jun-Young LEE

SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of